منابع مشابه
[High-density lipoproteins].
the accurate mechanism of how EIIC transports a sugar has not been clearly demonstrated yet. To investigate more detailed and accurate transportation mechanisms, we performed collective variable-based steered molecular dynamics (CVSMD) simulations. Our simulation shows the spontaneous transportation of the sugar toward the opposite side of the membrane with the preserved H-bonding interactions,...
متن کاملMaturation of high-density lipoproteins.
Human high-density lipoproteins (HDLs) are involved in the transport of cholesterol. The mechanism by which HDL assembles and functions is not well understood owing to a lack of structural information on circulating spherical HDL. Here, we report a series of molecular dynamics simulations that describe the maturation of discoidal HDL into spherical HDL upon incorporation of cholesterol ester as...
متن کاملCardioprotective Effects of High-Density Lipoproteins
The fact that a low level of high-density lipoprotein (HDL) cholesterol is highly predictive of future cardiovascular events has been established in population studies beyond all reasonable doubt. Furthermore, the evidence is overwhelming that the relationship is one of cause and effect rather than an epiphenomenon, with numerous studies in animals demonstrating that HDL-raising interventions t...
متن کاملStudies on Human Serum High Density Lipoproteins
Human serum apolipoprotein A-I (ape-A-I), the major protein component of the human serum high density lipoproteins, was studied in aqueous solutions of differing ionic strengths and pH by the techniques of sedimentation equilibrium ultracentrifugation and frontal analysis gel chromatography. The ultracentrifugal studies indicate that apo-A-I is a self-associating system that is dependent upon p...
متن کاملThe complexity of high-density lipoproteins.
In a 1984 review, Shlomo Eisenberg1 wrote, “In spite of their large number in plasma, it is difficult to define HDL as a vehicle for lipid transport ... other considerations must apply to this lipoprotein.” In this issue of Circulation, Suzuki et al2 report that high-density lipoprotein (HDL) suppresses the type I interferon response in macrophages challenged with lipopolysaccharide. They found...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Journal
سال: 2013
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-13-1025